Protein-Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation
Rebecca Sternke‐Hoffmann, Chang Liu, Xue Bing Wang, Hegne Pupart, Xun Sun, Jan Gui‐Hyon Dreiser, Peep Palumaa, Qinghua Liao, Matthias Krack, Jinghui Luo
This study identifies a redox mechanism in human serum albumin (HSA) that reduces Cu(II) to Cu(I) via disulphide bonds and conformational changes, revealing a new role for protein-mediated copper regulation.
Angewandte Chemie International Edition · Feb 27, 2026Peer-reviewedBiochemistry