Author

Daniel J. Spade

Brown UniversityORCID 0000-0002-4694-8724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:proteomics· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Poonam MehtaiD· 2 shared Adina BadeaiD· 1 shared Aditi Marehalli· 1 shared Andre GomesiD· 1 shared Angela R StermeriD· 1 shared August GuangiD· 1 shared Cindy Su· 1 shared Claire Gould· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Poonam MehtaORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 17, 2026

Dose-additive and dose-dependent fetal testis toxicity of a nine-phthalate mixture in the rat

Joceline Helmbreck, Ziqi Zhao, Poonam Mehta…·Daniel J. Spade

This study shows that a nine-phthalate mixture causes dose-additive fetal testis toxicity in rats, including MNGs and reduced testosterone, with the lowest effective dose for MNGs.

DOI 10.64898/2026.10.11.755118

ratproteomics

𝕏 PostBluesky

Pharmacology & ToxicologyToxicological SciencesPeer-reviewedJul 28, 2026

Ethylene Glycol Monomethyl Ether Altered Rat Sperm Small RNAs with Critical Developmental Roles

Yuan Pu, August Guang, Xinran Qi…·Daniel J. Spade

This study shows EGME exposure alters sperm small RNA profiles in rats, with dose-dependent changes in miRNAs, piRNAs, and tsRNAs, potentially affecting embryonic development.

DOI 10.1093/toxsci/kfag091

ratscRNA-seq

𝕏 PostBluesky