Adam J. H. Newton

The paper uses computer models to predict differential dendritic vulnerability to ischemia and spreading depression, finding greater calcium accumulation in basilar dendrites and higher intracellular chloride in distal apical dendrites during ischemia.

The paper develops a multiscale computer model of spreading depolarization in brain slices, showing that SD speed depends on tissue properties and is exacerbated by hypoxia and slice thickness.

The paper modernizes the NEURON simulator to improve sustainability, portability, and performance through new tools and optimizations.

The paper develops a 3D reaction-diffusion simulation method for neurons and networks, enabling accurate modeling of dynamics in complex geometries.

This study investigates the conditions for synaptic specificity during memory maintenance by simulating protein dynamics in dendritic spines.