NeurosciencebioRxivPreprint
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease
Kylene P. Daily, Asmaa Badr, Mostafa M. Eltobgy…·Amal O. Amer
This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.