Asmaa Badr

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

Gelsolin protects mitochondria and regulates inflammation during Legionella pneumophila infection

This study shows that gelsolin protects against Legionella pneumophila infection by maintaining mitochondrial health, reducing inflammation, and supporting neutrophil function.

AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.