Amy Webb

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

This study shows that NDUFB5 amplification in NSCLC drives tumor hypoxia and therapy resistance by increasing mitochondrial oxygen consumption.

This study shows that increased CPT1a expression protects the heart from pathological stress by suppressing harmful gene programs, and gene transfer can rescue cardiac function in disease models.

This study identifies altered alternative splicing and polyadenylation in glomerular genes during kidney disease models and demonstrates potential therapeutic modulation using antisense oligonucleotides.

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

This paper introduces GENN, a method for multi-omic interactome analysis that improves prediction of biomedical outcomes by learning salient associations in a low-dimensional space.

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.

The paper identifies distinct PPARγ mRNA variants in podocytes compared to adipose tissue, highlighting differences in splicing patterns and regulatory mechanisms.

This study investigates the association between predicted minor histocompatibility antigens (mHAs) and clinical outcomes in allogeneic hematopoietic cell transplantation using multivariate survival models.

This study compares the effects of GQ-16, a PPARγ partial agonist, and pioglitazone, a PPARγ full agonist, in treating nephrotic syndrome in rats, finding that GQ-16 reduces proteinuria and co-morbidities with fewer adipogenic side effects.

This study identifies IRF4 variants associated with increased risk of de novo AML and MDS through GWAS and TWAS analyses using the DISCOVeRY-BMT cohorts.