Author

Andrew J. McNamara

The Ohio State UniversityORCID 0000-0002-2645-6175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Amal O. AmeriD· 2 shared Amy WebbiD· 2 shared Asmaa BadriD· 2 shared Gauruv A. Gupta· 2 shared Hazem E. GhoneimiD· 2 shared Kylene P. DailyiD· 2 shared Maciej PietrzakiD· 2 shared Mostafa M. EltobgyiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Amal O. AmerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MicrobiologyJCI InsightPeer-reviewedSep 21, 2026

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Mostafa M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham…·Amal O. Amer

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

1 citation

mouseexperimental assay

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NeurosciencebioRxivPreprintAug 30, 2023

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease

Kylene P. Daily, Asmaa Badr, Mostafa M. Eltobgy…·Amal O. Amer

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.

4 citations

humanmouse

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