Mutational destabilisation accelerates the evolution of novel sensory and network functions
Yuki Kimura, Shigeko Kawai‐Noma, Daisuke Umeno
The paper shows that mutational destabilisation enables rapid evolution of novel sensory functions in AraC proteins through a BIF mechanism, outperforming traditional allosteric modes.
bioRxiv · Nov 23, 2023 · PreprintSynthetic Biology