Author

Daisuke Umeno

Waseda UniversityORCID 0000-0001-8107-552XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:E. coli· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Yuki KimuraiD· 2 shared Miyu Tsukada· 1 shared Shigeko Kawai‐NomaiD· 1 shared Yuki Yanai· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersSynthetic Biology

Yuki KimuraORCID

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2 papers

Recent·Most cited

Synthetic BiologyACS Synthetic BiologyPeer-reviewedApr 30, 2025

Fabrication, evolution, and mutual conversion of D-fucose-activatable and -repressible acetyltransferase upon mutations

Yuki Yanai, Miyu Tsukada, Yuki Kimura, Daisuke Umeno

The paper demonstrates how mutations can convert between D-fucose-activatable and -repressible acetyltransferase switches in fusion proteins.

1 citation

E. coliprotein structure

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintNov 23, 2023

Mutational destabilisation accelerates the evolution of novel sensory and network functions

Yuki Kimura, Shigeko Kawai‐Noma, Daisuke Umeno

The paper shows that mutational destabilisation enables rapid evolution of novel sensory functions in AraC proteins through a BIF mechanism, outperforming traditional allosteric modes.

2 citations

protein structureprotein sequence

𝕏 PostBluesky