Author

Marie Oestreich

German Center for Neurodegenerative DiseasesORCID 0000-0002-4754-1301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:diffusion model· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Joachim Ludwig SchultzeiD· 2 shared Anna C. AschenbrenneriD· 1 shared Arik HorneiD· 1 shared Barbara GattoiD· 1 shared Caterina CarraroiD· 1 shared Erinç MerdivaniD· 1 shared Jonas Schulte-SchreppingiD· 1 shared Kristian HändleriD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Joachim Ludwig SchultzeORCID

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Author profile →

2 papers

Recent·Most cited

DrugDiff - small molecule diffusion model with flexible guidance towards molecular properties

Marie Oestreich, Erinç Merdivan, Michael Lee, Joachim Ludwig Schultze, Marie Piraud, Matthias Becker

DrugDiff generates novel small molecules with desired properties using a diffusion model guided by predictors.

Journal of Cheminformatics · Feb 25, 2025Peer-reviewedBioinformatics

Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state

Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat‐Herresthal, Tim Helbing, Michele De Franco, Kristian Händler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C. Aschenbrenner, Joachim Ludwig Schultze, Barbara Gatto

This paper integrates transcriptome and chromatin state data to develop a scalable pipeline for drug discovery, predicting cancer cell line sensitivity and guiding compound development.

eLife · Aug 16, 2022Peer-reviewedSystems Biology