Author

Arik Horne

University of BonnORCID 0000-0002-4209-4573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anna C. AschenbrenneriD· 3 shared Joachim Ludwig SchultzeiD· 3 shared Kristian HändleriD· 3 shared Lorenzo BonaguroiD· 3 shared Jonas Schulte-SchreppingiD· 2 shared Kevin E. BassleriD· 2 shared Nico ReuschiD· 2 shared Stefanie Warnat‐HerresthaliD· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Anna C. AschenbrennerORCID

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3 papers

Recent·Most cited

Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state

Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat‐Herresthal, Tim Helbing, Michele De Franco, Kristian Händler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C. Aschenbrenner, Joachim Ludwig Schultze, Barbara Gatto

This paper integrates transcriptome and chromatin state data to develop a scalable pipeline for drug discovery, predicting cancer cell line sensitivity and guiding compound development.

eLife · Aug 16, 2022Peer-reviewedSystems Biology

Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs

Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Tatiana Hesse, Alexej Knaus, Yannick L. Riedel, Kristian Händler, Kevin E. Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Anna C. Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim Ludwig Schultze, Hubert Schorle

The paper generates synthetic embryo-like structures from ESCs through transcription factor-mediated reprogramming, showing implantation and decidual tissue formation.

bioRxiv · Jan 25, 2021 · PreprintSynthetic Biology

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

Kevin E. Bassler, Wataru Fujii, Theodore S. Kapellos, Arik Horne, Benedikt Reiz, Erika Dudkin, Malte D. Luecken, Nico Reusch, Collins Osei-Sarpong, Stefanie Warnat‐Herresthal, Allon Wagner, Lorenzo Bonaguro, Patrick Günther, Carmen Pizarro, Tina Schreiber, , Joachim Ludwig Schultze

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.

bioRxiv · May 28, 2020 · PreprintSystems Biology