Thomas Ulas

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state

This paper integrates transcriptome and chromatin state data to develop a scalable pipeline for drug discovery, predicting cancer cell line sensitivity and guiding compound development.

Creld2 function during unfolded protein response is essential for liver metabolism homeostasis

This study shows that Creld2 is essential for maintaining liver metabolism homeostasis by linking the unfolded protein response (UPR) to metabolic regulation, with sex-specific effects in fatty liver disease.

Swarm Learning as a privacy-preserving machine learning approach for disease classification

This paper introduces Swarm Learning, a decentralized machine learning approach for disease classification using transcriptomic data, demonstrating its effectiveness in developing classifiers for COVID-19, tuberculosis, and leukemias while preserving privacy.

The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms

This study identifies two independent mechanisms by which TRIM71 inhibits let-7 miRNA maturation and activity, impacting developmental and oncogenic processes.

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.

Memory-driven computing accelerates genomic data processing

This paper demonstrates that memory-driven computing significantly accelerates NGS data processing and reduces energy consumption for RNA-seq tasks.

Diagnostic value of blood gene expression-based classifiers as exemplified for acute myeloid leukemia

The paper develops robust and accurate classifiers for AML diagnosis using blood gene expression data and machine learning across 12,029 samples from 105 studies.

FASTGenomics: An analytical ecosystem for single-cell RNA sequencing data

FASTGenomics provides a secure, flexible, and user-friendly analytical ecosystem for single-cell transcriptomics data.

Cellular reprogramming of human monocytes is regulated by time-dependent IL4 signalling and NCOR2

This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.