In the same cell, the proteome defines cellular state and the transcriptome marks transitions
Marvin Thielert, Enes Ugur, Maximilian Zwiebel, Marc Oeller, Constantin Diekmann, Nils Eikmeier, Simon Suppinger, Lucas Diedrich, Sophia Steigerwald, Ankit Sinha, Prisca Liberali, Christoph Ziegenhain, Matthias Mann
The paper quantifies proteins and transcripts in the same cell, finding that the proteome defines stable cell states while the transcriptome reflects transitions.
bioRxiv · Aug 26, 2026 · PreprintSystems Biology