Prisca Liberali

The paper quantifies proteins and transcripts in the same cell, finding that the proteome defines stable cell states while the transcriptome reflects transitions.

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

Fractal introduces a task specification and platform for scalable, reproducible OME-Zarr-native bioimage analysis workflows, demonstrating reproducibility across diverse imaging data and clinical settings.

This study shows that cell size autonomously regulates the G1/S transition in mammalian epidermal stem cells, independent of extracellular signals.

This study develops a model to culture human intestinal organoids and identifies two stem cell states crucial for regeneration and lineage balance.

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

The paper introduces a dual-view light sheet microscope for live imaging of large multicellular systems at single-cell resolution and demonstrates its use on intestinal organoids and gastruloids.

This paper describes OME-Zarr, a cloud-optimized bioimaging file format developed through community collaboration to improve scalability and data access.

The paper quantifies morphological features of organoids under perturbations to identify constraints on their phenotypes, finding scaling relationships and parameter caps that vary with age and culture conditions.

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.

This paper develops a method for high fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins and light-sheet imaging.