Ayaan Hossain

The paper quantifies how genetic mutations affect enhancer activity and gene expression using a novel method and identifies TF-specific regulatory programs and enhancer-gene relationships.

This paper identifies critical steps and QC checkpoints for reproducibility of STARR-seq assays and provides guidelines for experimental design and analysis pipelines.

The paper develops a 346-parameter model to predict transcription initiation rates for bacterial promoters and enables automated promoter design.

The paper develops a machine learning model to predict DNA fragment synthesis success and identifies sequence determinants affecting synthesis outcomes.