Author

Pierre Goloubinoff

École Polytechnique Fédérale de LausanneORCID 0000-0002-4802-0807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Bruno FauvetiD· 3 shared Paolo De Los RiosiD· 2 shared Andrija FinkaiD· 1 shared Anne-Marie Cirinesi· 1 shared Manfredo QuadroniiD· 1 shared Marie‐Pierre Castanié‐CornetiD· 1 shared Mathieu Edouard RebeaudiD· 1 shared Pierre GenevauxiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMolecular Biology

Bruno FauvetORCID

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3 papers

Recent·Most cited

Is Hsp110 boosting the basal disaggregation activity Hsp70 by enhanced entropic pulling strokes?

Mathieu Edouard Rebeaud, Bruno Fauvet, Paolo De Los Rios, Pierre Goloubinoff

This study investigates how Hsp110 enhances Hsp70's disaggregation activity through entropic pulling by increasing effective volume.

Journal of Biological Chemistry · Jul 3, 2025Peer-reviewedBiochemistry

A novel fluorescent multi-domain protein construct reveals the individual steps of the unfoldase action of Hsp70

Satyam Tiwari, Bruno Fauvet, Salvatore Assenza, Paolo De Los Rios, Pierre Goloubinoff

This study uses a fluorescent reporter substrate to elucidate the stepwise mechanism of Hsp70 unfoldase action in converting aggregates into native proteins.

bioRxiv · Feb 17, 2022 · PreprintMolecular Biology

Bacterial Hsp90 mediates the degradation of aggregation-prone Hsp70-Hsp40 substrates preferentially by HslUV proteolysis

Bruno Fauvet, Andrija Finka, Marie‐Pierre Castanié‐Cornet, Anne-Marie Cirinesi, Pierre Genevaux, Manfredo Quadroni, Pierre Goloubinoff

The paper investigates the role of bacterial Hsp90 (HtpG) in collaboration with Hsp70 (DnaK) and shows that HtpG mediates degradation of aggregation-prone substrates via HslUV proteolysis.

bioRxiv · Oct 24, 2018 · PreprintMolecular Biology