Cancer target discovery enabled by transcriptome-based virtual CRISPR screening
Ananthan Sadagopan, Bingchen Li, Jiao Li, Yantong Cui, Riva Deodhar, Di Yang, Yifan Wu, Prathyusha Konda, Christy Biji, Dharma R. Thapa, Meha Thakur, Cary N. Weiss, Toni K. Choueiri, Jaimie H. Cheah, John G. Doench, , Srinivas Raghavan Viswanathan
This study uses machine learning to infer gene dependencies from tumor transcriptomes, identifying cancer vulnerabilities in rare cancers without experimental screening.
bioRxiv · Oct 24, 2024 · PreprintCancer Biology