Author

Bingchen Li

Harvard UniversityORCID 0000-0002-7895-2517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ananthan SadagopaniD· 3 shared Jiao LiiD· 3 shared Toni K. ChoueiriiD· 3 shared Cary N. WeissiD· 2 shared Meha Thakur· 2 shared Prateek KhannaiD· 2 shared Prathyusha KondaiD· 2 shared Qingru XuiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

Ananthan SadagopanORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 11, 2025

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma

Shikha Gupta, Prateek Khanna, Eddy Saad…·Srinivas R. Viswanathan

This study identifies CDK4/6 and mTORC1 pathway activation in tRCC and shows that their dual inhibition synergistically suppresses tRCC cell growth in vitro and xenografts in vivo.

DOI 10.1101/2025.07.11.663903

humanbulk RNA-seq

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Cancer BiologyNature MetabolismPeer-reviewedFeb 6, 2025

TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

Jiao Li, Kaimeng Huang, Meha Thakur…·Srinivas Raghavan Viswanathan

This study identifies TFE3 fusions driving OXPHOS in tRCC and reveals EGLN1 inhibition as a therapeutic target.

29 citationstop 1%

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintOct 24, 2024

Cancer target discovery enabled by transcriptome-based virtual CRISPR screening

Ananthan Sadagopan, Bingchen Li, Jiao Li…·Srinivas Raghavan Viswanathan

This study uses machine learning to infer gene dependencies from tumor transcriptomes, identifying cancer vulnerabilities in rare cancers without experimental screening.

5 citations

humanbulk RNA-seq

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