Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma
Prathyusha Konda, Alexandra J. Wakolbinger, Yantong Cui, Gabriel Roberti De Oliveira, Yasmin Nabil Laimon, Cary N. Weiss, Maxwell D. Seager, Riva Deodhar, Jiao Li, Sayed Matar, Jinyu Wang, Jack T. Horst, Sabrina Yvonne Camp, Aseman Bagheri Sheshdeh, Jonathan L. Hecht, , Srinivas Raghavan Viswanathan
This study identifies fusion-driven oncogenic programs in translocation renal cell carcinoma (tRCC) that shape an immunosuppressive tumor microenvironment, explaining its reduced immunotherapy response.
Nature Communications · Aug 26, 2026Peer-reviewedGenomics