Molecular BiologyJournal of NanobiotechnologyPeer-reviewed
Tetraspanin immunocapture phenotypes extracellular vesicles according to biofluid source but may limit identification of multiplexed cancer biomarkers
Rachel R. Mizenko, Terza Brostoff, Tatu Rojalin…·Randy P. Carney
The paper analyzes single extracellular vesicles to show that tetraspanin profiles vary by source but not isolation method, and that capture methods can bias apparent protein expression and diagnostic sensitivity.
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