Anna Fomitcheva Khartchenko

Proteo-Seq links chromatin accessibility and proteomic output in the same cell, revealing new protein-defined states in breast cancer cells.

The paper introduces VacTrap, a microfluidic device that isolates and spatially indexes single nuclei from mammalian cells with high efficiency, enabling single-cell multiomics applications.

EpiBlot maps chromatin accessibility and proteoform expression in HER2-expressing breast cancer cells, revealing distinct epigenetic and protein responses to therapies.

This paper develops a single-cell western blot method integrated with differential detergent fractionation to detect CK8 proteoforms while preserving nuclear integrity in breast cancer cells.