Microbially-conjugated Bile Salts Found in Human Bile Activate the Bile Salt Receptors TGR5 and FXR.
Ümran Ay, Martin Leníček, Raphael Silvanus Haider, Arno Claßen, Hans M.H. van Eijk, Kiran V.K. Koelfat, Gregory van der Kroft, Ulf P. Neumann, Carsten Hoffmann, Carsten Bolm, Steven W.M. Olde Damink, Frank G. Schaap
The paper identifies microbial bile salt conjugates that activate TGR5 and FXR receptors in human systems and quantifies their presence in blood and bile.
Hepatology Communications · Mar 22, 2024Peer-reviewedMolecular Biology