Chengsheng Zhu

This paper introduces a novel method to explore bacterial functional repertoires without reference databases, showing it outperforms existing approaches in taxonomic assignment and captures environment-driven diversity.

The paper analyzes snow microbiome metagenomes and metatranscriptomes to reveal functional diversity and activity, finding higher diversity in early spring and correlations between microbial pathways and organic acid levels.

fusionDB links microbial functions to environmental metadata through functional similarity networks, enabling comparisons and identification of horizontal gene transfer events.