Exercise engages a mechanically activated astrocyte state linking muscle activity to hippocampal plasticity
MD SADDAM HOSSAIN JOY, Ilber E. Manavbasi, Ki Yun Lee, Meghan G. Connolly, Quinlan Valkyrie Glueck, Movviz Ahmed, Mohammad Adel Zayyad, Younes Heidari, Bashar Emon, James Song, Yash Deswal, Daniel Lee, Joseph P. Ritchie, Nora Sripraram, Justin S. Rhodes, M. Taher A. Saif
This study identifies astrocyte contraction as a mechanism by which exercise signals from muscles influence hippocampal plasticity through increased proliferation and neuronal network modulation.
bioRxiv · Aug 8, 2026 · PreprintNeuroscience