Steeve D. Côté

Natural Microbial Enrichment Modulates Microglial States and Transcriptional Programs Relevant to Alzheimer's Disease

This study shows that introducing natural microbial environments to mice alters microglial states and transcriptional programs, increasing similarity to human Alzheimer's disease profiles.

Rapid loss of genetic variation and increased inbreeding in small and isolated populations of Norwegian wild reindeer

This study develops a high-density SNP array for reindeer and finds that small, isolated populations show rapid genetic variation loss and increased inbreeding, threatening their viability.

Island demographics and trait associations in white-tailed deer

The paper analyzes genetic diversity and trait associations in island white-tailed deer populations to identify genes linked to leucism, malocclusions, and body size.

Genomic health is dependent on long-term population demographic history

The paper examines how demographic history affects genomic health in three ungulates by analyzing inbreeding, constrained elements, and mutational load.

Copy number variations with adaptive potential in caribou (Rangifer tarandus): genome architecture and new annotated genome assembly

The paper improves the caribou genome assembly and identifies copy number variations (CNVs) associated with adaptation in different ecotypes.

Genomic architecture of artificially and sexually selected traits in a wild cervid

This study identifies polygenic loci associated with antler and body size in white-tailed deer using whole genome re-sequencing of phenotypically extreme pools.

Heritability estimates of antler and body traits in white-tailed deer (Odocoileus virginianus) from genomic-relatedness matrices

The paper estimates heritability of body and antler traits in free-ranging white-tailed deer using genomic-relatedness matrices and finds moderate heritability for body traits but low and variable heritability for antler traits.