Sébastien S. Hébert

This study shows that introducing natural microbial environments to mice alters microglial states and transcriptional programs, increasing similarity to human Alzheimer's disease profiles.

Indoor rewilding of SPF mice enhances pulmonary immune complexity and mechanics without compromising barrier integrity or introducing pathogens.

This study shows that miR-709 regulates NREM sleep EEG slow waves by linking glutamatergic signaling to neuronal activity through endosomal trafficking.

This study investigates miRNA biogenesis defects in HD brain tissue, finding downregulation of key enzymes and maturation defects, primarily in the striatum.

The paper shows sauna-like conditions and menthol treatment reduce tau phosphorylation through mild hyperthermia in mice and neuron-like cells.

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

The paper identifies FERMT2 as a key modulator of axon guidance and synaptic plasticity in an APP-dependent manner, linking its genetic risk variant to Alzheimer's disease through miRNA regulation.