Author

Bruce S Weir

University of WashingtonORCID 0000-0002-4883-1247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 7 Research Focus:benchmarking· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:database / resource· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Jérôme GoudetiD· 5 shared Jan GraffelmaniD· 3 shared André Silva Maróstica· 1 shared Diogo MeyeriD· 1 shared Eléonore LavanchyiD· 1 shared Erick C. CastelliiD· 1 shared Kelly NunesiD· 1 shared Nayane dos Santos Brito SilvaiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersGenetics

Jérôme GoudetORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Allelic Association Analyses: Estimation Recommendations

Bruce S Weir, Jérôme Goudet

The paper reviews methods for estimating inbreeding, relatedness, and population structure and proposes five recommendations for improving allele-sharing statistics.

Genetics · Apr 24, 2026Peer-reviewedGenomics

Estimation of Jacquard's genetic identity coefficients with bi-allelic variants by constrained least-squares

Jan Graffelman, Bruce S Weir, Jérôme Goudet

This paper proposes a constrained least squares method to estimate Jacquard's genetic identity coefficients and related parameters, showing computational efficiency comparable to maximum likelihood methods.

Heredity · Nov 7, 2024Peer-reviewedGenetics

Detecting inbreeding depression in structured populations

Eléonore Lavanchy, Bruce S Weir, Jérôme Goudet

This study compares methods for quantifying inbreeding depression in structured populations using simulated and empirical data, finding that weighted gamete correlation and specific GRM matrices improve estimation.

Proceedings of the National Academy of Sciences · Apr 30, 2024Peer-reviewedGenomics

The transitivity of the Hardy-Weinberg law

Jan Graffelman, Bruce S Weir

The paper demonstrates the transitivity of the Hardy-Weinberg law for multi-allelic polymorphisms and shows its application in genetic data analysis and testing for equilibrium.

Forensic Science International Genetics · Mar 9, 2022Peer-reviewedGenetics

Population structure in the MHC region

André Silva Maróstica, Kelly Nunes, Erick C. Castelli, Nayane dos Santos Brito Silva, Bruce S Weir, Jérôme Goudet, Diogo Meyer

The paper examines genetic diversity at HLA loci in the MHC region, showing that while SNPs show low FST values, haplotype frequencies vary geographically, impacting bone-marrow transplantation.

bioRxiv · Oct 25, 2021 · PreprintGenetics

Multi-allelic Exact tests for Hardy-Weinberg equilibrium that account for gender

Jan Graffelman, Bruce S Weir

The paper extends exact tests for Hardy-Weinberg equilibrium to multi-allelic variants, accounting for gender differences in X-chromosomal and autosomal data.

Molecular Ecology Resources · Dec 30, 2017Peer-reviewedGenetics

A Unified Characterization ofPopulation Structure and Relatedness

Bruce S Weir, Jérôme Goudet

The paper redefines population structure and relatedness by introducing parameters based on differences in identity by descent probabilities, providing new estimates sensitive to rare variants and suitable for association studies.

Genetics · May 26, 2017Peer-reviewedGenetics