Diogo Meyer

Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (Sao Paulo, Brazil)

This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

Population structure in the MHC region

The paper examines genetic diversity at HLA loci in the MHC region, showing that while SNPs show low FST values, haplotype frequencies vary geographically, impacting bone-marrow transplantation.

Immunogenetics of resistance to SARS-CoV-2 infection in discordant couples

The paper identifies genetic variants associated with resistance to SARS-CoV-2 infection by analyzing discordant Brazilian couples.

Expression estimation and eQTL mapping for HLA genes with a personalized pipeline

The paper develops a personalized pipeline to estimate HLA gene expression and map eQTLs, showing improved accuracy and better eQTL results compared to standard methods.

Population Differentiation at the HLA Genes

The paper examines population differentiation at HLA genes under balancing selection, finding reduced differentiation globally but higher differentiation in closely related populations.

Signatures of long-term balancing selection in human genomes

The paper introduces NCD2, a statistic to detect long-term balancing selection in human genomes, finding it affects 0.6% of genomic windows and 0.8% of positions, with many novel targets.

Mapping bias overestimates reference allele frequencies at the HLA genes in the 1000 Genomes Project phase I data

The paper evaluates genotype calls and allele frequency estimates at HLA genes in 1000 Genomes Project data, finding significant overestimation of reference allele frequencies due to mapping bias.