Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Nevin K Zacharia, Stefanie Kuhns, Niels Boegholm, Anni Christensen, Jiaolong Wang, Narcis-Adrian Petriman, Anna Lorentzen, Jindřiška Leischner Fialová, Lucie Menguy, Sophie Saunier, Søren T. Christensen, Jens Andersen, Sagar Bhogaraju, Esben Lorentzen
This study identifies a U-box-like domain in IFT172 that mediates ciliary signaling and protein stability, linking it to ciliopathy pathogenesis.
eLife · Jun 23, 2026Peer-reviewedBiochemistry