DEFICIENCY OF THE NUTRIENT SENSOR CPT1c IN SF1 NEURONS DISRUPTS THE ENDOCANNABINOID SYSTEM RESULTING IN COMPROMISED SATIETY AND FUEL SELECTION UPON FAT INTAKE
Anna Fosch, DS Pizarro, Sebastián Zagmutt, Ana Cristina Reguera, Gerard Batallé, M Rodríguez-García, Jesús García-Chica, Óscar Freire-Agulleiro, Cristina Miralpeix, Philippe Zizzari, Dolors Serra, Laura Herrero, Miguel López, Daniela Cota, Rosalía Rodríguez‐Rodríguez, Núria Casals
This study shows that CPT1c in SF1 neurons is critical for satiety and fat metabolism during high-fat diet exposure, as its deficiency leads to impaired metabolic responses and increased obesity.
bioRxiv · Jan 23, 2024 · PreprintNeuroscience