Philippe Zizzari

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

This study shows that CPT1c in SF1 neurons is critical for satiety and fat metabolism during high-fat diet exposure, as its deficiency leads to impaired metabolic responses and increased obesity.

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.