Daniela Cota

A Female-Specific Microglial Redox Program Gates Susceptibility to Obesity

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells

This study shows that cannabidiol inhibits HIV-1 transmission by targeting multiple immune cells and blocking viral infection and transfer in mucosal tissues.

Extracellular DNASE1L3 dysfunction fuels obesity-driven inflammation and metabolic syndrome

This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

DEFICIENCY OF THE NUTRIENT SENSOR CPT1c IN SF1 NEURONS DISRUPTS THE ENDOCANNABINOID SYSTEM RESULTING IN COMPROMISED SATIETY AND FUEL SELECTION UPON FAT INTAKE

This study shows that CPT1c in SF1 neurons is critical for satiety and fat metabolism during high-fat diet exposure, as its deficiency leads to impaired metabolic responses and increased obesity.

POMC neurons functional heterogeneity relies on mTORC1 signaling

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders

This study shows that deleting S6K1 in adult mice causes anxiety-like behaviors and learning deficits, linked to reduced hippocampal neurogenesis and neuronal atrophy.

Time-dependent roles of adolescent- and adult-born dentate granule neurons in spatial learning

This study compares the role of adolescent- and adult-born dentate granule neurons in spatial learning and finds that their ontogenetic stage determines their involvement in memory processes.

Top-down control of water intake by the endocannabinoid system

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.