This study compares the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models to identify gene expression patterns associated with RNAemia and clinical symptoms.

The Journal of Infectious Diseases · Jun 25, 2026Peer-reviewedImmunology

Immune gene expression changes more during a malaria transmission season than between consecutive seasons.

Kieran Tebben, Salif Yirampo, Drissa Moriba Coulibaly, Abdoulaye Kassoum Kone, Matthew Brent Laurens, Emily M. Stucke, Ahmadou Dembélé, Youssouf Tolo, Karim Traoré, Amadou Niangaly, Andrea A. Berry, Bourèma Kouriba, Christopher V. Plowe, Ogobara K. Doumbo, Kirsten E. Lyke, , David Serre

The paper compares immune gene expression changes during a malaria transmission season versus between seasons in children with P. falciparum infections.

Microbiology Spectrum · Aug 20, 2024Peer-reviewedBioinformatics

Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

Kara A. Moser, Elliott Franco Drábek, Ankit Dwivedi, Emily M. Stucke, Jonathan Crabtree, Antoine Dara, Zalak Shah, Matthew Adams, Tao Li, Priscila T. Rodrigues, Sergey Koren, Adam M. Phillippy, James B. Munro, Amed Ouattara, Benjamin C. Sparklin, , Joana Caldeira Fernandes da Silva

The paper compares genome structure, sequence, and immunogenic potential of Plasmodium falciparum strains used in vaccine trials and finds significant differences affecting vaccine efficacy.

Genome Medicine · Jan 8, 2020Peer-reviewedGenomics