Adam Tully Waickman

This study identifies BCR-dependent enhancement (BDE) as a mechanism by which DENV infects B cells, showing that BCR-E protein interactions and dynamin-mediated entry are critical for viral replication in these cells.

This study compares the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models to identify gene expression patterns associated with RNAemia and clinical symptoms.

The paper uses single-cell multi-omics to analyze DENV-1 infection, revealing interferon-driven immune responses and cell-type interactions in human blood.

The paper develops a serologic assay to measure antibodies against Aedes aegypti salivary proteins D7L1+2 as a marker of vector exposure and finds they correlate with dengue virus infection burden.

The paper uses scRNA-seq to show that monocyte IL1B expression inversely correlates with HIV-1 reservoir size in ART-treated individuals.

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

This study uses scRNA-seq to compare transcriptomic responses of DENV-infected and bystander macrophages under ADE and conventional infection, revealing distinct gene expression patterns and pathways.

This study shows DENV structural proteins are surface-expressed on infected cells and can be targeted by antibodies for phagocytic clearance, bypassing ADE risks.

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.