Christopher J. Derrick

This study shows that loss of primary cilia in second heart field cells causes bicuspid aortic valve by disrupting Notch-Jag1 signaling and altering valve leaflet formation.

This study shows that zebrafish arterial valve development is conserved with mammalian valve leaflets and can be used for testing BAV variants.

This study identifies Llgl1's role in regulating the timely establishment of the epicardium and apical laminin sheath during cardiac ventricle development in zebrafish.

This study identifies a role for laminin in zebrafish heart development by showing that Lamb1a limits SHF addition to the atrium, preventing excessive growth and morphogenesis defects.

The paper identifies asymmetric Hapln1a expression in zebrafish heart development, showing it drives ECM expansion and promotes asymmetric heart morphogenesis through interaction with laterality cues.