Ahlam Alqahtani

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This paper reviews clinical and demographic features of IGH::CEBP-rearranged BCP-ALL cases and introduces new cases to encourage further study of this rare subtype.

This paper creates a 3D epigenomic roadmap of human B-cell differentiation, revealing regulatory mechanisms in immunity and cancer.

This study shows that loss of primary cilia in second heart field cells causes bicuspid aortic valve by disrupting Notch-Jag1 signaling and altering valve leaflet formation.

This study shows that zebrafish arterial valve development is conserved with mammalian valve leaflets and can be used for testing BAV variants.

This study uses spatial transcriptomics to analyze human embryonic arterial valves, identifying novel genes and pathways involved in valve development and highlighting limitations in current genomic databases.