Molecular basis of noncanonical complement C3 activation by histamine
Francisco José Fernández, Karla de la Paz-García, Javier Querol-García, Carlos A. Ramos-Guzmán, Héctor Martín Merinero, Israel Mares‐Mejía, Lucía Alfonso‐González, Santiago Rodríguez de Córdoba, Iñaki Tuñón, M. Cristina Vega
This study identifies histamine as a novel activator of complement C3, forming C3h which accelerates complement activation and inflammation.
bioRxiv · Dec 14, 2025 · PreprintBiochemistry