Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer
Nomeda Girnius, Tuulia Vallius, Wenqing Chen, Inga-Maria P. Launonen, Sara Palomino‐Echeverría, Jia‐Ren Lin, Caitlin E. Mills, Saila Kauppila, Pauliina Kronqvist, Antti Ellonen, Merja Perälä, Eloise Withnell, Yu‐An Chen, Maria Secrier, Sandro Santagata, , Anniina Färkkilä
The paper maps oxidative stress response in TNBC using single-cell and spatial data, identifying GCLC+ mesenchymal tumor cells linked to better patient outcomes.
bioRxiv · Nov 6, 2025 · PreprintCancer Biology