Caitlin E. Mills

Polypharmacology is an enduring and nearly universal property of kinase inhibitors

This paper shows that kinase inhibitors commonly target multiple kinases, independent of approval status, and highlights the need for better understanding of their polypharmacology.

Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer

The paper maps oxidative stress response in TNBC using single-cell and spatial data, identifying GCLC+ mesenchymal tumor cells linked to better patient outcomes.

Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method

The paper introduces a method called Dye Drop for high-throughput single-cell assays in 384-well plates, enabling detailed dose-response analysis of small molecules in breast cancer cell lines.

A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

Paired evaluation defines performance landscapes for machine learning models

This study introduces paired evaluation to improve performance estimation of machine learning models in drug response and disease severity prediction, showing up to 30% variation in performance estimates based on test data choice.

Temporal and spatial topography of cell proliferation in cancer

This study quantifies cell proliferation in tumors using multiplexed imaging and identifies spatial and temporal patterns of cell cycle regulation.