Author

Wyatt Travis Clark

BioMarin (United States)ORCID 0000-0002-5041-3669Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Guoying Karen YuiD· 2 shared Jonathan H. LeBowitziD· 2 shared Marena I. TrinidadiD· 2 shared Teague Sterling· 2 shared Ailin Glagovsky· 1 shared Akash Kamandula· 1 shared Amanda M. WilliamsiD· 1 shared Amanda R. Luu· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Guoying Karen YuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A

Shantanu Jain, Marena I. Trinidad, Thanh Nguyen, Kaiya Jones, Santiago Diaz Neto, Fang Ge, Ailin Glagovsky, Cameron Jones, Giankaleb Moran, Boqi Wang, Kobra Rahimi, Sümeyra Zeynep Çalıcı, Luis R. Cedillo, Silvia Berardelli, Buse Özden, , Wyatt Travis Clark

The paper evaluates variant effect predictions for ARSA gene variants, finding that a bootcamp-trained model outperformed others and that deep learning slightly improved performance over simpler methods.

Human Genetics · Mar 1, 2025Peer-reviewedGenetics

Identifying therapeutic drug targets for rare and common forms of short stature

Karol Estrada, Steven Froelich, Arthur Wüster, Christopher R. Bauer, Teague Sterling, Wyatt Travis Clark, Yuanbin Ru, Marena I. Trinidad, Hong Phuc Nguyen, Amanda R. Luu, Daniel J. Wendt, Gouri Yogalingam, Guoying Karen Yu, Jonathan H. LeBowitz, Lon R. Cardon

The paper identifies bidirectional effect genes associated with short stature using GWAS data and validates their therapeutic potential through functional assays and clinical trial success.

bioRxiv · Apr 2, 2020 · PreprintGenetics

Utilizing ExAC to Assess the Hidden Contribution of Variants of Unknown Significance to Sanfilippo Type B Incidence

Wyatt Travis Clark, Guoying Karen Yu, Mika Aoyagi-Scharber, Jonathan H. LeBowitz

The paper estimates the contribution of variants of unknown significance to Sanfilippo Type B incidence using functional activity data and population allele frequencies.

PLoS ONE · Jul 6, 2018Peer-reviewedBioinformatics