Author

Christopher R. Bauer

Geisinger Health SystemORCID 0000-0002-4172-6719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:electronic health records· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Sarah A. PendergrassiD· 2 shared Ailin Falkmo Hansen· 1 shared Alexandra HavdahliD· 1 shared Allan I PackiD· 1 shared Amanda R. Luu· 1 shared Anne E. JusticeiD· 1 shared Antti LatvalaiD· 1 shared Archie I CampbelliD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Sarah A. PendergrassORCID

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Author profile →

4 papers

Recent·Most cited

Within-sibship GWAS improve estimates of direct genetic effects

Laurence J Howe, Michel Guillaume Nivard, Tim Morris, Ailin Falkmo Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klarić, , Neil M Davies

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

bioRxiv · Mar 5, 2021 · PreprintGenetics✦ In-depth digest

Characterization of Genetic and Phenotypic Heterogeneity of Obstructive Sleep Apnea Using Electronic Health Records

Olivia J. Veatch, Christopher R. Bauer, Navya Shilpa Josyula, Diego R. Mazzotti, Brendan T Keenan, Kanika Bagai, Beth Ann Malow, Janet D. Robishaw, Allan I Pack, Sarah A. Pendergrass

The paper identifies genetic variants associated with obstructive sleep apnea using electronic health records and links them to comorbidities.

BMC Medical Genomics · Jul 25, 2020Peer-reviewedGenetics

Identifying therapeutic drug targets for rare and common forms of short stature

Karol Estrada, Steven Froelich, Arthur Wüster, Christopher R. Bauer, Teague Sterling, Wyatt Travis Clark, Yuanbin Ru, Marena I. Trinidad, Hong Phuc Nguyen, Amanda R. Luu, Daniel J. Wendt, Gouri Yogalingam, Guoying Karen Yu, Jonathan H. LeBowitz, Lon R. Cardon

The paper identifies bidirectional effect genes associated with short stature using GWAS data and validates their therapeutic potential through functional assays and clinical trial success.

bioRxiv · Apr 2, 2020 · PreprintGenetics

Characterizing and Managing Missing Structured Data in Electronic Health Records

Brett K. Beaulieu‐Jones, Daniel R. Lavage, John W Snyder, Jason H. Moore, Sarah A. Pendergrass, Christopher R. Bauer

The paper evaluates imputation methods for missing structured data in EHRs using clinical lab measures from 602,366 patients, showing some methods perform well while others are unsuitable for multiple imputation.

JMIR Medical Informatics · Feb 23, 2018Peer-reviewedBioinformatics