Author

Amanda R. Luu

BioMarin (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Gouri YogalingamiD· 2 shared Jonathan H. LeBowitziD· 2 shared Arthur WüsteriD· 1 shared Brett E. CrawfordiD· 1 shared Bryan K. Yip· 1 shared Christopher R. BaueriD· 1 shared Daniel J. WendtiD· 1 shared Guoying Karen YuiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Gouri YogalingamORCID

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2 papers

Recent·Most cited

Identifying therapeutic drug targets for rare and common forms of short stature

Karol Estrada, Steven Froelich, Arthur Wüster, Christopher R. Bauer, Teague Sterling, Wyatt Travis Clark, Yuanbin Ru, Marena I. Trinidad, Hong Phuc Nguyen, Amanda R. Luu, Daniel J. Wendt, Gouri Yogalingam, Guoying Karen Yu, Jonathan H. LeBowitz, Lon R. Cardon

The paper identifies bidirectional effect genes associated with short stature using GWAS data and validates their therapeutic potential through functional assays and clinical trial success.

bioRxiv · Apr 2, 2020 · PreprintGenetics

BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.

Gouri Yogalingam, Amanda R. Luu, Heather Prill, Melanie J. Lo, Bryan K. Yip, John Holtzinger, Terri Christianson, Mika Aoyagi-Scharber, Roger Lawrence, Brett E. Crawford, Jonathan H. LeBowitz

This study characterizes two distinct cellular uptake mechanisms for BMN 250 in Sanfilippo B disease, showing CI-MPR-mediated uptake in neurons and astrocytes and receptor-independent uptake in microglia.

PLoS ONE · Jan 18, 2019Peer-reviewedGenetics