Cancer Evolvability Determines Therapy Outcomes
Ranjini Bhattacharya, Anuraag Bukkuri, Robert A. Gatenby, Joel S. Brown
This paper develops an evolutionary model to show how cancer evolvability affects therapy outcomes, finding that targeted therapy is better for low-evolvability cancers and chemotherapy for high-evolvability ones, with a combined approach effective against facultative evolvability.
Evolutionary Applications · Oct 1, 2026Peer-reviewedCancer Biology