Author

Laurent Sabbagh

Université de MontréalORCID 0000-0002-5097-4298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Arturo D. Mancini· 1 shared Bong‐Ki HongiD· 1 shared Boubacar Sidiki TraoreiD· 1 shared Christian Le GouilliD· 1 shared Chul‐Soo Cho· 1 shared Eunbyeol Choi· 1 shared Hiroyuki KobayashiiD· 1 shared Jayhyun Kim· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Arturo D. Mancini

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Unconventional Interplay Between GPCRs and RTKs Signaling Pathways Through SH2 Domain-Containing Proteins

Pedro Henrique Scarpelli Pereira, Arturo D. Mancini, Boubacar Sidiki Traore, Hiroyuki Kobayashi, Viktoriya Lukasheva, Christian Le Gouill, Laurent Sabbagh, Michel Bouvier

This study identifies a novel mechanism where Gq/11 and G12/13 activation causes SH2 domain-containing proteins to translocate from the plasma membrane to the nucleus, reducing RTK signaling activity.

bioRxiv · Apr 3, 2026 · PreprintCell Biology

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

Naeun Lee, Bong‐Ki Hong, Sungyong You, Riri Kwon, Jihoon Kwon, Eunbyeol Choi, Kang-Gu Lee, Yu-Mi Kim, Yingjin Li, Jayhyun Kim, Young-Jun Park, Yeonseok Chung, Sin‐Hyeog Im, Laurent Sabbagh, Chul‐Soo Cho, Wan‐Uk Kim

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

bioRxiv · Jun 28, 2024 · PreprintImmunology