Author

Silvia Jansen

Washington University in St. LouisORCID 0000-0002-5119-367XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ankit GargiD· 1 shared DeHaven J. McCraryiD· 1 shared Kory J. LavineiD· 1 shared Lina GreenbergiD· 1 shared Michael J. GreenbergiD· 1 shared Rui ZhangiD· 1 shared Teri NaismithiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperBiophysics

Ankit GargORCID

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2 papers

Recent·Most cited

Domain-specific folding of the tandem β-propeller protein Coronin 7 (Coro7) by CCT/TRiC

DeHaven J. McCrary, Teri Naismith, Silvia Jansen

This study identifies Coronin 7 as a CCT/TRiC substrate and shows that CCT/TRiC interacts specifically with the first β-propeller domain of Coro7.

Journal of Biological Chemistry · Feb 6, 2026Peer-reviewedBiochemistry

Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility

Ankit Garg, Silvia Jansen, Lina Greenberg, Rui Zhang, Kory J. Lavine, Michael J. Greenberg

This study shows that the ACTA1 R256H mutation disrupts actin structure and function in cardiomyocytes, leading to reduced contractility and a likely causative role in dilated cardiomyopathy.

Proceedings of the National Academy of Sciences · Nov 6, 2024Peer-reviewedBiophysics