Rui Zhang

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

This study shows that pathogenic MAPT mutations impair microglial lysosomal and autophagic functions, affecting tau clearance and degradative capacity.

Coupling of tubulin acetylation to microtubule stabilization through molecular mimicry

This study identifies MTCL1 as a factor linking microtubule stabilization and acetylation, showing its role in neuronal function through molecular mimicry.

Mechanism of how the universal module XMAP215 γ-TuRC nucleates microtubules

This study identifies how XMAP215 interacts with γ-TuRC to promote microtubule nucleation through specific TOG domains and reveals structural insights into their cooperative function.

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation

The paper identifies NINL as a modulator of tau aggregation through integrative genomic and functional analyses linking it to proteostasis dysfunction in FTD and AD.

Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance

This study determines the cryo-EM structure of SSNA-1 and shows its self-assembly and microtubule-binding role in centriole maintenance and embryonic viability.

The Nuclease Domain of E. coli RecBCD Regulates DNA Binding and Base Pair Melting

This study shows that the RecB nuclease domain in E. coli RecBCD regulates DNA binding and base pair melting through allosteric effects and linker interactions.

HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2

This study shows HURP stabilizes microtubules and works with TPX2 to promote branching microtubule nucleation during spindle assembly in Xenopus egg extract.

Automated model building and protein identification in cryo-EM maps

ModelAngelo combines convolutional and graph neural networks with protein language model embeddings and hidden Markov model searches to automate atomic model building and identify unknown proteins in cryo-EM maps.

Integrated Model of the Vertebrate Augmin Complex

The paper presents an integrated model of the vertebrate augmin complex using cryo-EM, structural prediction, and electron microscopy, revealing its structure, conservation, and microtubule binding site.