Author

Zitian Tang

Washington University in St. LouisORCID 0000-0002-5159-5695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:variant calling· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Sheng Chih JiniD· 3 shared Zefan LiiD· 3 shared Andrew RuttenbergiD· 2 shared Benjamin K. JohnsoniD· 2 shared Benpeng MiaoiD· 2 shared Chad TomlinsoniD· 2 shared Daofeng LiiD· 2 shared Edward A. BelteriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Sheng Chih JinORCID

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3 papers

Recent·Most cited

Leveraging Human Pangenome for Improved Somatic Variant Detection

Qichen Fu, Zilan Xin, Benpeng Miao, Wenjin Zhang, Nahyun Kong, Zitian Tang, Andrew Ruttenberg, Derek Albracht, Edward A. Belter, John E. Garza, Chad Tomlinson, Elvisa Mehinovic, Jiawei Shen, Xiaoyu Zhuo, Shihua Dong, , Ting Wang

This study shows that using graph-based pangenomes and inferred donor-specific assemblies improves somatic variant detection compared to GRCh38.

bioRxiv · Jan 5, 2026 · PreprintGenomics

A Pangenomic Method for Establishing a Somatic Variant Detection Resource in HapMap Mixtures

Nahyun Kong, Zitian Tang, Andrew Ruttenberg, Juan F Macias-Velasco, Zefan Li, Wenjin Zhang, Benpeng Miao, Zilan Xin, Qichen Fu, Haeorum Park, Xiaoyu Zhuo, Elvisa Mehinovic, Edward A. Belter, Chad Tomlinson, John E. Garza, , Sheng Chih Jin

The paper develops a pangenomic method to create a benchmark resource for somatic variant detection using HapMap mixtures, identifying millions of variants across different genomic regions.

bioRxiv · Sep 29, 2025 · PreprintGenomics

Heterozygous and Homozygous RFC1 AAGGG Repeat Expansions are Common in Idiopathic Peripheral Neuropathy

Zitian Tang, Sinem Seleme Övünç, Ryo Iwase, Elle Mehinovic, Simone Thomas, Jenna Ulibarri, Zefan Li, Dustin Baldridge, Carlos Cruchaga, Matt Johnson, Jeffrey Milbrandt, Brian Christopher Callaghan, PNRR Study Group, Ahmet Höke, Peter K. Todd, Sheng Chih Jin

The paper identifies RFC1 AAGGG repeat expansions in idiopathic peripheral neuropathy patients using a new computational pipeline and finds both heterozygous and homozygous expansions contribute to the condition.

medRxiv · Apr 18, 2025 · PreprintGenetic & Genomic Medicine