Author

Sinem Seleme Övünç

University of MichiganORCID 0000-0002-3125-3145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter K. ToddiD· 2 shared Ahmet HökeiD· 1 shared Amy Krans· 1 shared Brian Christopher CallaghaniD· 1 shared Carlos CruchagaiD· 1 shared Dustin BaldridgeiD· 1 shared Elizabeth M.H. TankiD· 1 shared Elle Mehinovic· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Peter K. ToddORCID

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2 papers

Recent·Most cited

Heterozygous and Homozygous RFC1 AAGGG Repeat Expansions are Common in Idiopathic Peripheral Neuropathy

Zitian Tang, Sinem Seleme Övünç, Ryo Iwase, Elle Mehinovic, Simone Thomas, Jenna Ulibarri, Zefan Li, Dustin Baldridge, Carlos Cruchaga, Matt Johnson, Jeffrey Milbrandt, Brian Christopher Callaghan, PNRR Study Group, Ahmet Höke, Peter K. Todd, Sheng Chih Jin

The paper identifies RFC1 AAGGG repeat expansions in idiopathic peripheral neuropathy patients using a new computational pipeline and finds both heterozygous and homozygous expansions contribute to the condition.

medRxiv · Apr 18, 2025 · PreprintGenetic & Genomic Medicine

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats

Yi‐Ju Tseng, Amy Krans, Indranil Malik, Xiexiong Deng, Evrim Yildirim, Sinem Seleme Övünç, Elizabeth M.H. Tank, Karen R. Jansen‐West, Ross T. Kaufhold, Nicolás Gómez, Roger B. Sher, Leonard Petrucelli, Sami J. Barmada, Peter K. Todd

The paper shows that ribosomal quality control factors reduce toxic repeat-associated non-AUG translation from GC-rich repeats by preventing ribosomal stalling.

Nucleic Acids Research · Feb 19, 2024Peer-reviewedMolecular Biology