Ahmet Höke

This study shows chronic CaMKII activation drives skeletal muscle aging and sarcopenia, and partial inhibition in aged muscle improves function and shifts the transcriptome toward a youthful state.

This study shows that transplanting motor neurons into chronically denervated nerves delays the adoption of a chronic denervation phenotype, maintaining Schwann cells in a pro-regenerative state.

This study identifies molecular myelin architecture disruptions in CMT1A and HNPP models, linking PMP22 dosage to myelin defects and disease pathogenesis.

This study shows that lack of m6A methylation in Schwann cells causes demyelination and regenerative failure in mice.

The paper identifies RFC1 AAGGG repeat expansions in idiopathic peripheral neuropathy patients using a new computational pipeline and finds both heterozygous and homozygous expansions contribute to the condition.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

The paper shows that conditioned medium from painful schwannomatosis tumors sensitizes sensory neurons more than nonpainful tumors, indicating secreted factors contribute to pain variability.

This study shows that MCT1 in Schwann cells is essential for maintaining sensory nerve myelination during aging, leading to hypomyelination and impaired function.