Author

Amy Sirr

ORCID 0000-0002-5186-9692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:variant effect prediction· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Aimée M. DudleyiD· 4 shared Gareth A. CromieiD· 4 shared Russell S. LoiD· 3 shared Andrea Lynne GropmaniD· 2 shared Hiroki MorizonoiD· 2 shared Ljubica CaldoviciD· 2 shared Michelle TangiD· 2 shared Nicholas Ah MewiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersGenetics

Aimée M. DudleyORCID

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4 papers

Recent·Most cited

GeneticsG3 Genes Genomes GeneticsPeer-reviewedJul 3, 2026

CYClones: A highly powered, fully genotyped, 8-parent yeast mapping population

Gareth A. Cromie, Russell S. Lo, Trey S. Morgan…·Aimée M. Dudley

CYClones is a yeast mapping population with high genetic diversity and power to detect low-heritability variants, enabling genetic dissection of complex traits.

DOI 10.1093/g3journal/jkag179

yeastwhole-genome sequencing

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedJun 17, 2026

Functional Profiling of 2,193 ASS1 Missense Variants: Insights into Variant Pathogenicity and Epistatic Interactions in Citrullinemia Type I

Russell S. Lo, Gareth A. Cromie, Michelle Tang…·Aimée M. Dudley

The paper functionally profiles 2193 ASS1 missense variants to determine their pathogenicity and epistatic interactions in Citrullinemia Type I.

DOI 10.1371/journal.pgen.1012167

humanexperimental assay

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GeneticsPLoS ONEPeer-reviewedDec 5, 2024

Spatiotemporal Patterns of Gene Expression During Development of a Complex Colony Morphology

Gareth A. Cromie, Zhihao Tan, Michelle Hays…·Aimée M. Dudley

The paper analyzes gene expression patterns in yeast colonies to understand how genetic and spatial factors influence colony structure development.

2 citations

yeastbulk RNA-seq

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GeneticsThe American Journal of Human GeneticsPeer-reviewedMay 1, 2023

The functional impact of 1,570 SNP-accessible missense variants in human OTC

Russell S. Lo, Gareth A. Cromie, Michelle Tang…·Aimée M. Dudley

The paper develops a high-throughput functional assay to assess the impact of 1,570 OTC missense variants, improving variant interpretation using ACMG/AMP guidelines.

25 citationstop 3%

humanDNA methylation

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